Naferline acetate (Synarel) is drug that promotes the
release of gonadotropin-releasing hormone (GnRH).
GnRH is normally released from the hypothalamus (a
structure in the lower part of the brain) and stimulates
the body to produce estrogen. Nafarelin acetate is used
which the tissue that normally lines the inside of the
uterus is found outside the uterus. This tissue is known
as the endometrium. The uterus is a hollow organ in a
female's body where the egg is implanted and the fetus
The massive increase of GnRH caused by nafarelin acetate overwhelms the body and
causes the ovaries to shut down estrogen production. This helps treat endometriosis
because there is evidence that estrogen promotes this disease. Estrogen is a type of
hormone that promotes the growth of some physical female sexual characteristics.
Nafarelin acetate is also used to treat premature puberty in boys and girls since it
decreases the amount of estrogen (and testosterone) in the blood. Puberty is the period
of life in which the ability to reproduce begins, which usually begins between the ages of
11 and 13. Testosterone is a type of hormone that promotes the growth of some physical
male sexual characteristics. Nafarelin acetate is sprayed into one nostril in the morning
and the other nostril at night. It is only available as a nasal spray.